Osteosarcomas of the Head and neck (HNOS) are an infrequent disease, representing less than 10% of all osteosarcomas, and 1% of all head and neck cancers. However, they exhibit a different clinical behavior and natural history than extremities osteosarcomas (OS), therefore requiring an specific study and analysis. Specifically, in head and neck sites, OS have shown a different presentation age, reduced likelihood of distant metastases, and a severely higher local recurrence rates. This may be due to the difficulties in ensuring wide negative margins, given the multiple vital structures surrounding  tumors in this particular region.  This singular features render HNOS a different prognosis and prognostic factors,  becoming a topic that should be assessed independently, as they may need a different treatment approach than osteosarcomas of the trunk or extremities. There still is deep controversy about the timing and orden in which the therapeutic approach for multimodality treatment should be planned, understanding that, most commonly, patients require surgery and chemotherapy. Extension of surgery and Chemotherapeutic agents are also very variable among different treating centers. There is little quality evidence to shed more light on a treatment with better outcomes, due to its infrequency; however, the only way to obtain more accurate information that would help us reach more consensus on its management would probably be to carry out better and larger collaborative and multicenter studies.

Ingrid Plass is a 35 year old Head and neck Surgeon and researcher from Chile, she has finishes her Head and Neck Surgery Fellowship at Universidad del Desarrollo, after her General Surgery Residency, at Universidad de Chile at Santiago de Chile and completed an Global Online Fellowship at IFHNOS (International  Federation of Head and Neck Oncology Societies) a well as the GCSRT - Global Clinical Scholars  Research Training program at Harvard University, USA. She is now staff member of head and neck surgery team at Instituto Nacional del Cancer  and also Clinica Alemana de Santiago, where she directs the Head and Neck Cancer Research program.