Background: Canal wall down surgery still remains a common operation among patients with chronic suppurative otitis media, especially for those ones with cholesteatoma. Large size of post-operation cavity, its incomplete epithelialization lead to permanent inflammation worsening regenerative processes in the middle ear. Different methods are suggested in order to reduce the size of a trepanation cavity but most of them have serious drawbacks. Bioactive glass granules which contain osteotrophic minerals and are capable of osteointegration provide a great potential in solving this problem.

Objective: Evaluate the results of using bioactive glass granules in reduction of trepanation cavities upon middle ear operations.

Methods: Bioactive glass granules named “Biosit-Eclor” with the size of 0.3-0.5 mm were used intraoperatively to obliterate trepanation cavities with volume from 1 to 2 sm³. All of the 37 participants of the research had canal wall down mastoidectomy, 31 of them also had tympanoplasty of different types conducted. The regeneration processes evaluation included collecting complaints, otomicroscopy results and CTscan.

Results: 21 patients were examined in a few months after the operation. All of them had complete epithelialization of the trepanation cavity and none of them had had any cases of discharge from the ear. According to the computed tomography results, in most cases there was no clear border between the bone and the “Biosit-Elcor” mass. 

Conclusion: To sum it up, using bioactive glass granules may be a great way to solve the problem of large trepanation cavities after the middle ear surgery because of its easy application and good biocompatibility. 

TBA